Marcelino dismissed but Valencia keep pressure on Barcelona
Real Madrid coach Zinedine Zidane shrugged off his first setback since taking over from the sacked Rafa Benitez after his new team could only manage a 1-1 draw at Real Betis in La Liga.
The result also means second-placed Real Sociedad can reclaim top spot if they beat Eibar on Sunday.
Photos from the Champions League matches played across Europe on Tuesday.
Triple European champions Manchester United and their under-fire coach Louis van Gaal face a tricky task against little-known Midtjylland in the last 32 of the Europa League following Monday's draw.
Real fought back after a calamitous own goal from keeper Keylor Navas gave Betis the lead in the 25th minute, just after the Costa Rican escaped a possible red card. Cristiano Ronaldo pulled the hosts level in the 41st with a diving header.
Real Madrid coach Zinedine Zidane is under pressure to break up his misfiring attacking trio of Cristiano Ronaldo, Karim Benzema and Gareth Bale when he takes the La Liga leaders to Alaves on Saturday.
'I haven't lost any strength in the last four days and in one sense I feel a little relieved but focused on the objectives we set for ourselves at the start of the season'
Barcelona are in the middle of an injury crisis as they head to Valencia for Saturday's La Liga game looking to keep up with pacemaking pair Atletico Madrid and Real Madrid. Without injured goalkeeper Jasper Cillessen and right back Sergi Roberto for the last two games, Barca will also be missing defenders Jordi Alba and Gerard Pique after both were hurt in Wednesday's 4-0 win over Manchester City in the Champions League. Pique sprained his right ankle while Alba injured his left hamstring and both are out until November.
Struggling Rayo win at Valladolid after late penalty save
IMAGES from the soccer matches played in Spain and Italy on Saturday
The Portuguese can expect a hostile reception in Valencia, who had to suffer 15 of his goals for Real Madrid and are returning to the Champions League for the first time in three years.
AC Milan, Villarreal and Nice reached the knockout stage of the Europa League after posting wins on Thursday in the penultimate round of the group stage.
Jose Callejon took advantage of Napoli's numerical advantage in the 48th minute of the playoff round second leg tie, handing them an away goal which, added to their 2-0 win from the first leg, effectively ended Nice's challenge as it left the French side needing to score four goals.
A Romelu Lukaku hat-trick in a 4-1 win for Everton at Young Boys and a thrilling 3-3 draw between Celtic and Inter Milan.
Real Madrid returned to winning ways after last weekend's drubbing at Atletico but failed to convince and were whistled by their own fans during a drab 2-0 victory at home to Deportivo La Coruna on Saturday.
News of all that transpired on and off the football field.
Images from football matches played across Europe on Sunday.
Manchester United flirted with calamity before coasting into the Europa League last 16 as debutant Marcus Rashford helped them overcome an early blow with two goals in a 5-1 home victory over Midtjylland on Thursday.
Chelsea's Marcos Alonso and Real Madrid's Nacho were notable absentees in defence, along with Atletico Madrid midfielder Koke.
Barcelona have completed their business in the latest transfer window and the Spanish and European champions' squad is now "closed", president Josep Bartomeu said on Thursday.
Gary Neville's disappointing start as Valencia coach continued when the ambitious Singapore-owned club drew 2-2 at home to lowly Rayo Vallecano in La Liga on Sunday, prompting more rumblings of discontent from the fans.
Here are five talking points from the weekend's action:
Real Madrid put their title defence back on track with a comfortable 3-1 win over Real Sociedad at Anoeta on Sunday, despite missing several key players. Sociedad defender Kevin Rodrigues scored at both ends and Borja Mayoral and Gareth Bale netted Madrid's other goals to help them equal the consecutive scoring record of 73 games set by Pele's Santos between 1961 and 1963.
Borussia Dortmund snatched a late goal at Atalanta to progress with a 1-1 draw, while AC Milan and Atletico Madrid, both with three-goal leads from the away legs, completed the formality of qualifying with 1-0 wins at home on Thursday.
Real Madrid will have their combative Spain centre back Sergio Ramos available for Saturday's "clasico" against Barcelona but Wales winger Gareth Bale is out, coach Carlo Ancelotti said on Friday.
Barcelona midfielder Xavi raised the King's Cup aloft alongside Andres Iniesta in his final appearance at the Camp Nou on Saturday and now victory in the Champions League would make it a perfect send-off for the club legend.
Manchester City have signed French central defender Aymeric Laporte from Spanish club Athletic Bilbao, the Premier League leaders said on Tuesday.
The Bavarians have now won the German league title a record 29 times.
European champions Real Madrid will face former champions Liverpool, FC Basel and debutants Ludogorets of Bulgaria following the draw for the group stage of the Champions league on Thursday.
News of all that's transpired on and off the football field
New Liverpool boss Juergen Klopp made it three wins from his last three matches with a 1-0 success at Rubin Kazan in Russia that left them second in Group B, two points behind Swiss club Sion on Thursday.
Atletico Madrid striker Antoine Griezmann struck twice as the Spanish side outclassed hapless Olympique de Marseille 3-0 on Wednesday to win the Europa League for the third time.
Barcelona have been haunted by their recent failures in the Champions League and there are concerning signs for the Catalans as they prepare for Tuesday's last-16 first leg away to Olympique Lyonnais.
Outgoing Spain coach Vicente del Bosque has no regrets as he prepares to leave his post at the end of July after eight years in charge during which they won the World Cup and Euro 2012.
A mesmeric Lionel Messi helped Barcelona to come from behind and beat Sevilla 2-1 in a thrilling encounter on Sunday as the champions kept the pressure on La Liga leaders Real Madrid, who saw off Leganes 3-0 thanks to a double from Gareth Bale.
Barcelona coach Luis Enrique said he was shocked by the wild knee-high challenge on world player of the year Lionel Messi that triggered a straight red card for Atletico Madrid's Brazilian defender Filipe Luis on Saturday. The coach, whose side won 2-1 at home to go three points clear in La Liga, protested angrily on the touchline after the left back's studs-up tackle against the Argentine forward shortly before half time. "Did you see my reaction? Then you can imagine what I was thinking. It shocked me but I am not going to go into details about it," he told a news conference at the Nou Camp.
With a fifth world player of the year award safely tucked away in the trophy cabinet, Lionel Messi can set his sights on one of the next milestones in his remarkable career: reaching 500 goals for club and country. The Barcelona and Argentina forward can add to his jaw-dropping tally of 479 in 609 official games -- 430 for Barca and 49 for his national team -- in Sunday's La Liga match at home to Athletic Bilbao. The 28-year-old from Rosario, who picked up the FIFA Ballon d'Or on Monday, is looking close to his best following a two-month injury layoff late last year and netted a hat-trick when second-placed Barca crushed Granada 4-0 at the Nou Camp last weekend in their most recent outing in Spain's top flight.
Fresh from propelling Barcelona to their fifth trophy of 2015, their prolific strikes are now seeking to break the Spanish record of goals in a calendar year when they play Real Betis on Wednesday.
A Marco Asensio-inspired Real Madrid crushed Eibar 3-0 to close the gap on La Liga leaders Barcelona to five points on Sunday, with Karim Benzema starting on the bench.